www.sciencedaily.com
Researchers have identified the immune enzyme OTULIN as a key trigger for toxic tau buildup in the brain. When OTULIN was disabled in preclinical models, tau vanished from neurons, and brain cells remained healthy. These findings challenge long-held beliefs that tau is essential for neuron survival, suggesting it may actually be a byproduct of inflammation. Consequently, OTULIN is emerging as a potential master switch for controlling inflammation and preventing age-related cognitive decline, offering a promising new target for treating Alzheimer’s and brain aging.
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