www.sciencedaily.com
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Tryptophan is essential for brain health, serving as a precursor for serotonin and melatonin to regulate mood and sleep. However, as the brain ages or develops neurological diseases, tryptophan metabolism is disrupted by an enzyme called IDO1. Instead of producing beneficial neurotransmitters, this pathway shifts toward creating neurotoxic metabolites like quinolinic acid. These harmful byproducts contribute to oxidative stress and inflammation, which are linked to cognitive decline, memory loss, and mood disorders. Consequently, maintaining proper tryptophan balance is critical for preventing neurodegeneration and supporting cognitive function throughout the aging process.
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